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Dulaglutide and liraglutide were linked with higher rates of abdominal pain, nausea/vomiting, constipation, and diarrhea compared with semaglutide and exenatide

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Four medications were assessed: semaglutide, tirzepatide, naltrexone/bupropion (Contrave, Currax Pharmaceuticals) and phentermine/topiramate

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Underexplored peptide systems frequently encounter attrition after biological validation but before pharmacologic optimization, whereas GLP-1 progressed through these stages following the introduction of enabling technologies